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11-08-2016, 05:51 AM
Post: #1
Vitamin D has immunologic activity independent of its crucial role in calcium regulation (12). Animal models of autoimmune disease have shown beneficial effects of vitamin D as an immunosuppressant. For example, murine models of human RA demonstrated both decreased incidence and severity of disease in mice treated with active vitamin D (3). Evidence supporting an effect of vitamin D in RA specifically also is derived from clinical observations. Manolagas et al found that a significantly greater proportion of seropositive RA patients (76%) had lymphocytes possessing vitamin D receptors compared with controls (18%) (13). Within the rheumatoid joint, the active form of vitamin D has been shown to be synthesized in RA synovium and is thought to be stimulated by interleukin-1 (IL-1) and/or IL-2 (14). Locally produced vitamin D may act in a paracrine manner to decrease T cell responsiveness through the inhibition of cellular proliferation and reduction in lymphokine production when confronted by an inappropriate and overly exuberant immune response
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